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Codon pattern and compositional constraints determination of genes associated with chronic periodontitis

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dc.contributor.authorKhandia, Rekha
dc.contributor.authorPandey, Megha
dc.contributor.authorVladimirovich Rzhepakovsky, Igor
dc.contributor.authorAli Khan, Azmat
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-11T10:49:49Z
dc.date.available2024-07-11T10:49:49Z
dc.date.issued2022-10-24
dc.description© 2022 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Genes. To access the final edited and published work see https://doi.org/10.3390/genes13111934
dc.description.abstractGenome-wide association studies showed the relationship of NIN, ABHD12B, WHAMM, AP3B2, and SIGLEC5 with chronic periodontitis. The study’s objective was to investigate different molecular patterns and evolutionary forces acting on the mentioned genes. The investigation of molecular patterns encompasses the study of compositional parameters, expression profile, physical properties of genes, codon preferences, degree of codon bias, determination of the most influential codons, and assessment of actions of evolutionary forces, such as mutations and natural selection. The overall compositional analysis revealed the dominance of A and G nucleotides compared to T and C. A relatively low codon usage bias is observed. The CTG codon is the most overused codon, followed by TCC. The genes, AP3B2 and SIGLEC5, preferred GC-ending codons, while NIN, ABHD12B, and WHAMM preferred AT-ending codons. The presence of directional mutational force and natural selection was found to operate codon usage in genes envisaged, and selective forces were dominant over mutational forces. Apart from mutation and selection forces, compositional constraints also played imperative roles. The study enriched our knowledge of specific molecular patterns associated with the set of genes significantly associated with chronic periodontitis. Further studies are warranted to identify more genetic signatures associated with the disease.es
dc.formatapplication/pdfes
dc.format.extent13es
dc.identifier.citationGenes 2022, 13(11), 1934
dc.identifier.doihttps://doi.org/10.3390/genes13111934
dc.identifier.issnElectronic: 2073-4425
dc.identifier.urihttp://hdl.handle.net/10201/143008
dc.languageenges
dc.publisherMDPI
dc.relationThe research was funded by Researchers Supporting Project (RSP-2021/339), King Saud University, Riyadh, Saudi Arabia and project R-1007/2018, University of Murcia.es
dc.relation.publisherversionhttps://www.mdpi.com/2073-4425/13/11/1934
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectChronic periodontitises
dc.subjectInflammatory diseasees
dc.subjectCodon usagees
dc.subjectGenetics relationship of periodontitises
dc.titleCodon pattern and compositional constraints determination of genes associated with chronic periodontitises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoveryb83b4b59-2d61-40f0-9108-5c6a6d158295
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