Publication: The flavonoid apigenin delays forgetting of passive avoidance conditioning in rats
Authors
Caballero Bleda, María ; Benavente-García, Obdulio ; Castillo, Julián ; Popovic Popovic, Miroljub
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Publisher
SAGE Publications
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DOI
https://doi.org/10.1177/0269881113512040
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info:eu-repo/semantics/article
Description
© The Author(s) 2013. © 2014 SAGE Publications. This document is the Published version of a Published Work that appeared in final form in Journal of Psychopharmacology. To access the final edited and published work see https://doi.org/10.1177/0269881113512040
Abstract
The present experiments were performed to study the effect of the flavonoid apigenin (20 mg/kg intraperitoneally (i.p.), 1 h before acquisition), on 24 h retention performance and forgetting of a step-through passive avoidance task, in young male Wistar rats. There were no differences between saline- and apigenin-treated groups in the 24 h retention trial. Furthermore, apigenin did not prevent the amnesia induced by scopolamine (1mg/kg, i.p., 30 min before the acquisition). The saline- and apigenin-treated rats that did not step through into the dark compartment during the cut-off time (540 s) were retested weekly for up to eight weeks. In the saline treated group, the first significant decline in passive avoidance response was observed at four weeks, and complete memory loss was found five weeks after the acquisition of the passive avoidance task. At the end of the experimental period, 60% of the animals treated with apigenin still did not step through. These data suggest that 1) apigenin delays the long-term forgetting but did not modulate the 24 h retention of fear memory and 2) the obtained beneficial effect of apigenin on the passive avoidance conditioning is mediated by mechanisms that do not implicate its action on the muscarinic cholinergic system.
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Citation
Journal of Psychopharmacology, 2014, Vol. 28, N. 5, pp. 498-501.
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