Publication: Clinical-pathological study of the healing of wounds provoked on the dorso-lingual mucosa in 186 albino rats
Authors
Camacho Alonso, Fabio ; López Jornet, María Pía
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Publisher
Wiley
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DOI
https://doi.org/10.1016/j.otohns.2006.06.1243
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info:eu-repo/semantics/article
Description
© 2007 American Academy of Otolaryngology–Head and Neck Surgery Foundation. This document is the Published version of a Published Work that appeared in final form in Otolaryngology - Head and Neck Surgery. To access the final edited and published work see https://doi.org/10.1016/j.otohns.2006.06.1243
Abstract
Objective
To evaluate wound healing of incisions created in the upper aerodigestive tract.
Study design and setting
In this prospective and blind study, 186 adult rats were assigned to six groups to create incisions in the tongue. In the first three groups, the wounds were made with a steel scalpel; no substance was applied to the wound in the first group, but N-butyl-2-cyanoacrylate was applied in the second group, and trichloroacetic acid at 50 percent in the third group. In the fourth, fifth, and sixth groups, the wounds were caused by cryosurgery, electrocautery, and CO2 laser. Hemostasis, postoperative oral intake, and wound healing were measured. Statistical analysis was performed with analysis of variance.
Results
The wounds to which N-butyl-2-cyanoacrylate was applied showed no hemorrhaging and faster reepithelialization and resolution of the inflammatory response.
Conclusions
N-butyl-2-cyanoacrylate is a good hemostatic for managing wounds in the oral mucosa provoked by steel scalpel.
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Citation
Otolaryngology - Head and Neck Surgery, 2007, Vol. 136, N. 1, pp. 119-124,
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