Synthesis and Reactivity of Model Intermediates Proposed for the Pd-Catalyzed Remote C−H Functionalization of N‐(2- Haloaryl)acrylamides

Pérez-Gómez, Marta; Navarro, Leticia; Saura-Llamas, Isabel; Bautista, Delia; Lautens, Mark; García-López, José-Antonio

Publication:
Synthesis and Reactivity of Model Intermediates Proposed for the Pd-Catalyzed Remote C−H Functionalization of N‐(2- Haloaryl)acrylamides

dc.contributor.author	Pérez-Gómez, Marta
dc.contributor.author	Navarro, Leticia
dc.contributor.author	Saura-Llamas, Isabel
dc.contributor.author	Bautista, Delia
dc.contributor.author	Lautens, Mark
dc.contributor.author	García-López, José-Antonio
dc.contributor.department	Química Inorgánica
dc.date.accessioned	2021-01-28T11:42:48Z
dc.date.available	2021-01-28T11:42:48Z
dc.date.created	2017
dc.date.issued	2017-11-14
dc.description.abstract	We have studied the possible reaction pathways operating in the Pd-catalyzed remote C–H functionalization of N-(2-haloaryl)-acrylamides from an organometallic approach. We have isolated and characterized several reaction intermediates, such as σ-alkyl-Pd complexes and spiro C,C-palladacycles, and evaluated the role of the base and the auxiliary ligands coordinated to Pd in the remote C–H activation process. In addition, the reactivity of these intermediates toward different unsaturated species like benzyne, alkynes or isocyanides has been studied in order to gain further insight on the reaction mechanism leading to functionalized spiro-oxoindoles.	es
dc.format	application/pdf	es
dc.identifier.citation	Organometallics, 2017, 36, 4465-4476
dc.identifier.doi	10.1021/acs.organomet.7b00702
dc.identifier.issn	1520-6041
dc.identifier.uri	http://hdl.handle.net/10201/101950
dc.language	eng	es
dc.relation	Ámbito del proyecto: nacional Agencia/entidad financiadora: MINECO Convocatoria: 2015 Nombre del proyecto: Synthesis and Applications in Catalysis and Photocatalysis of New Types of Transition Metal Organometallic Complexes (CTQ2015-69568-P) Código: CTQ2015-69568-P Ámbito del proyecto: regional Agencia/entidad financiadora: FUNDACIÓN SÉNECA Convocatoria: 2015 Synthesis, Structure and Reactivity of New Types of Organometallic Complexes. Applications as Synthetic Intermediates, Catalysts and Photoactive Materials. (19890/GERM/15) Código: 19890/GERM/15	es
dc.relation.isreplacedby	https://doi.org/10.1021/acs.organomet.7b00702	es
dc.relation.publisherversion	https://doi.org/10.1021/acs.organomet.7b00702	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 España	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/es/	*
dc.subject	Palladium	es
dc.subject	C–H activation	es
dc.subject	catalysis	es
dc.subject	organometallic complexes	es
dc.subject	spirocycles	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::54 - Química	es
dc.title	Synthesis and Reactivity of Model Intermediates Proposed for the Pd-Catalyzed Remote C−H Functionalization of N‐(2- Haloaryl)acrylamides	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es