Publication:
Beyond p16 immunostaining: an overview of biomarkers in anal squamous intraepithelial lesions

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dc.contributor.authorAlbuquerque, Andreia
dc.contributor.authorRios, Elisabete
dc.contributor.authorMedeiros, Rui
dc.date.accessioned2022-06-13T10:43:06Z
dc.date.available2022-06-13T10:43:06Z
dc.date.issued2019
dc.description.abstractHistological grading of squamous intraepithelial lesions or intraepithelial neoplasia is fundamental for clinical management and for assessment of the risk of progression. Biomarkers are important for assisting correct grading of these lesions, reducing inter and intraobserver variability and most promising, for prognosis. Although p16 is the most studied biomarker in this setting, there are several other biomarkers that have been studied, reflecting also the need to find a better single or association option that can be more suitable, especially for classification purposes. A PubMed and Embase search was conducted from their inception until April 2018, aiming to identify biomarkers evaluated in histological samples of anal squamous intraepithelial lesions, other than p16. Information on “Ki-67”, “ProEx™ C”, “p53”, “human papillomavirus L1 capsid protein”, “stathmin-1”, “minichromosome maintenance protein”, “p21”, “proliferating cell nuclear antigen”, “histones”, “human papillomavirus E4”, “chromosomal abnormalities” and “methylation” was collected and reviewed. From these, the most studied biomarker was by far Ki-67. In many cases there were few studies performed for each biomarker, with no clear standardized interpretation of the immunostaining. An increased positive rate with more severe grades of lesions was shown in many cases. Prognostic data are limited and need to be further validated.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and Histopathology, Vol.34, nº3, (2019)
dc.identifier.doiDOI: 10.14670/HH-18-053
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/121211
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAnal squamous intraepithelial lesionses
dc.subjectAnal intraepithelial neoplasiaes
dc.subjectBiomarkerses
dc.subjectImmunohistochemistryes
dc.subjectMethylationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleBeyond p16 immunostaining: an overview of biomarkers in anal squamous intraepithelial lesionses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34, nº3 (2019)