Publication: Prognostic value of bronchioloalveolar carcinoma component in lung adenocarcinoma
Authors
Lin, D.M. ; Ma, Y. ; Zheng, S. ; Liu, X.Y. ; Zou, S.M. ; Wei, W.Q.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
BAC is a common pattern in conventional
lung adenocarcinoma. In the past, however, there were
no well-defined criteria for BAC. As a result, it was
difficult to evaluate the prognosis on this type of lung
adenocarcinoma. Though the 1999 WHO classification
of BAC provides a useful framework, it does not provide
detailed enough information to predict prognosis in lung
adenocarcinomas with BAC feature. The aim of this
study was to address the prognostic value of
bronchioloalveolar carcinoma (BAC) component in lung
adenocarcinoma.
Ninety-one consecutive surgically treated patients
with adenocarcinoma exhibiting various degrees of BAC
features and complete follow-up records were
retrospectively studied. According to the percentage of
BAC component designed as less than 50%, 50%-79%,
80%-99%, and 100% , tumors were classified as type I,
type II, type III, and type IV respectively. The overall 5-
year survival rate was 64.84%. Multivariate analysis
revealed that the four classified types are independent
prognostic factors (P=0.0008), as is tumor stage
(P=0.0000). The 5-year survival rates were 39.29%,
58.82%, 81.25%, 85.71% for the four classified types
respectively, and were 88.89% for stage I, 46.15% for stage II, and 23.81% for stage III. However, the size of
tumor (>2 cm) was significant only in the univariate
analysis (P=0.0275). In the patients with tumor size
exceeding 2 cm in diameter, the BAC component was
also significant to predict prognosis (p=0.0008).
In lung adenocarcinoma, the BAC component may
prove to be useful to predict the outcome of the patients,
and the percentage of BAC pattern and pathological
stage appear to be two independent prognostic factors.
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