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Telomerase reverse transcriptase delays aging in cancer-resistant mice.

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dc.contributor.advisorBlasco, MarĆ­a Antonia
dc.contributor.authorTomas Loba, Antonia
dc.contributor.authorFlores, Ignacio
dc.contributor.authorFernandez-Marcos, Pablo J
dc.contributor.authorCayuela, Maria L
dc.contributor.authorMaraver, Antonio
dc.contributor.authorTejera, Agueda
dc.contributor.authorBorras, Consuelo
dc.contributor.authorMatheu, Ander
dc.contributor.authorKlatt, Peter
dc.contributor.authorFlores, Juana M
dc.contributor.authorViƱa, Jose
dc.contributor.authorSerrano, Manuel
dc.contributor.authorBlasco, Maria
dc.contributor.departmentFisiologĆ­a
dc.coverage.temporalsiglo XXes
dc.date.accessioned2024-02-07T07:56:43Z
dc.date.available2024-02-07T07:56:43Z
dc.date.issued2008-11-14
dc.descriptionĀ©2008 Elsevier Inc. This document is the Published version of a Published Work that appeared in final form in Cell. To access the final edited and published work see https://doi.org/10.1016/j.cell.2008.09.034
dc.description.abstractTelomerase confers limitless proliferative potential to most human cells through its ability to elongate telomeres, the natural ends of chromosomes, which otherwise would undergo progressive attrition and eventually compromise cell viability. However, the role of telomerase in organismal aging has remained unaddressed, in part because of the cancer-promoting activity of telomerase. To circumvent this problem, we have constitutively expressed telomerase reverse transcriptase (TERT), one of the components of telomerase, in mice engineered to be cancer resistant by means of enhanced expression of the tumor suppressors p53, p16, and p19ARF. In this context, TERT overexpression improves the fitness of epithelial barriers, particularly the skin and the intestine, and produces a systemic delay in aging accompanied by extension of the median life span. These results demonstrate that constitutive expression of Tert provides antiaging activity in the context of a mammalian organism.es
dc.embargo.terms1-ene-2999
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.doihttps://doi.org/10.1016/j.cell.2008.09.034
dc.identifier.issnPrint: 0092-8674
dc.identifier.issnElectrĆ³nico: 1097-4172
dc.identifier.urihttp://hdl.handle.net/10201/138804
dc.languageenges
dc.publisherCell Presses
dc.relationFundacĆ­on Marcelino Botin Ministry of Science and Innovation of Spain Spanish Association Against Cancer European Commissiones
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectTERT
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Ciencias biolĆ³gicas en general:577 - 577 BioquĆ­mica. BiologĆ­a molecular. BiofĆ­sica
dc.titleTelomerase reverse transcriptase delays aging in cancer-resistant mice.es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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