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Time-dependent and lesion-dependent HMGB1-selective localization in brains of patients with cerebrovascular diseases

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dc.contributor.authorUmahara, Takahiko
dc.contributor.authorUchihara, Toshiki
dc.contributor.authorHirokawa, Katsuiku
dc.contributor.authorHirao, Kentaro
dc.contributor.authorShimizu, Soichiro
dc.contributor.authorHashimoto, Takao
dc.contributor.authorTerasi, Hiroo
dc.contributor.authorHanyu, Haruo
dc.date.accessioned2022-03-28T11:43:58Z
dc.date.available2022-03-28T11:43:58Z
dc.date.issued2018
dc.description.abstractHigh mobility group box 1 protein (HMGB1) has multiple functions, including the maintenance of nucleosomes and the regulation of gene transcription. HMGB1 is released from activated macrophages, resulting in the induction of inflammatory cytokines. Recently, much research about the role of HMGB1 in cerebrovascular disease (CVD) has been reported. In an animal model, HMGB1 neutralization ameliorates brain infarction, there is an early release of HMGB1 from neurons, and HMGB1 antibody attenuates delayed cerebral vasospasm in experimental subarachnoid hemorrhage. It was also reported that elevation of HMGB1 in serum correlates with severity of acute intracerebral hemorrhage. However, the evidence of HMGB1 localization in brains of patients with CVD is very limited. Therefore, we investigated at autopsy the immunolocalization of HMGB1 in brains of patients with CVD (acute and chronic cerebral infarction, acute cerebral hemorrhage, subarachnoid hemorrhage). In 3 out of 10 acute cerebral infarction cases, the cytoplasm of neurons located around the ischemic core (i.e., penumbra) was positive for HMGB1. In the chronic stage of cerebral infarction, macrophages located in some ischemic regions were positive for HMGB1. Around the hematoma in the basal ganglia, HMGB1-like immunoreactivity (IR) was intense in macrophages. However, around the subarachnoid hematoma, HMGB1- like IR was not seen in the cortex. In arteries surrounded by subarachnoid hematoma, HMGB1-like IR was located in the cytoplasm of vascular smooth muscle cells. These findings, which partially differ from animal model results, may provide translational research and a basis for understanding the role of HMGB1 in brains of patients with CVD.es
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dc.format.extent8es
dc.identifier.citationHistology and Histopathology, Vol.33, nÂş2, (2018)
dc.identifier.doiDOI: 10.14670/HH-11-914
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/118388
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHMGB1es
dc.subjectCerebral infarctiones
dc.subjectCerebral hemorrhagees
dc.subjectSubarachnoid hemorrhagees
dc.subjectPenumbraes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleTime-dependent and lesion-dependent HMGB1-selective localization in brains of patients with cerebrovascular diseaseses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.33, nÂş2 (2018)