Publication:
Cox and mesothelioma: an overview

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Cox and mesothelioma an overview.pdf(184.94 KB)
Date
2005
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Authors
Cardillo, I. ; Spugnini, E.P. ; Verdina, A. ; Galati, R. ; Citro, G. ; Baldi, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cyclooxygenases catalyze the rate limiting step in the production of prostanoids. Accumulating data demonstrate that overexpression of these enzymes, and in particular of cyclooxygenases-2, promotes multiple events involved in tumorigenesis; in addition, numerous studies show that inhibition of cyclooxygenases-2 can delay or prevent certain forms of cancer. Malignant mesothelioma is a lethal pleural, peritoneal and pericardial neoplasia that actually lacks valid therapies and in which cyclooxygenases-2 is recognized as an important adverse prognostic factor. Hence, there is an increasing interest in the development of new treatments based on cyclooxygenases-2 inhibitors, to prolong survival and even potentially cure this neoplasia.
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Mesothelioma , Chemotherapy
Citation
URI
http://hdl.handle.net/10201/22554
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Collections
Histology and histopathology Vol.20, nº 4 (2005)
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