Publication: The distribution and role of myofibroblasts and CD34-positive stromal
cells in normal pancreas and various pancreatic lesions
Authors
Kuroda, Naoto ; Toi, M. ; Nakayama, Hiroyuki ; Miyazaki, E. ; Yamamoto, M. ; Hayashi, Yoshihiro ; Hiroi, Makoto ; Enzan, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
To elucidate the distribution and role of
myofibroblasts and CD34-positive stromal cells in
various pancreatic lesions, we performed an
immunohistochemical study using a streptoavidin-biotin
immunoperoxidase technique. We selected 43 pancreatic
lesions from 1 biopsied, 22 surgically resected and 12
autopsied specimens: acute pancreatitis (n=3), chronic
non-obstructive pancreatitis (n=4), obstructive
pancreatitis (n=7), islet cell tumor (n=4), serous
cystadenoma (n=7), mucinous cystadenoma (n=6), and
invasive ductal carcinoma (n=12). In normal pancreas,
myofibroblasts and CD34-positive stromal cells were
predominantly present in the peridcutal and periacinar
areas, respectively. Both myofibroblasts and CD34-
positive cells were observed in the stroma of chronic
pancreatitis. In four islet cell tumors, myofibroblasts
were present in the stroma of the tumor center, but no
CD34-positive stromal cells were identified.
Additionally, myofibroblasts and CD34-positive stromal
cells were located in the inner layer and the outer layer
of the capsule of three islet cell tumors, respectively. In
nine of the thirteen cystadenomas, only myofibroblasts
were recognized in the cyst wall. In the remaining four
cystadenomas, a small number of CD34-positive cells
were observed in the cyst wall. In 12 invasive ductal
carcinomas, the stroma possessed a lot of
myofibroblasts, but there were no or few CD34-positive
stromal cells. In conclusion, it seems that the abundant amount of CD34-stromal cells in the main lesions is
characteristic of chronic inflammatory lesions.
Myofibroblasts and CD34-positive stromal cells may
play a role in regulating the tumor growth in the capsule
of islet cell tumors of the pancreas.
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