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Measurement of Creatine kinase and Aspartate aminotransferase in saliva of dogs: a pilot study

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dc.contributor.authorTvarijonaviciute, Asta
dc.contributor.authorBarranco, Tomás
dc.contributor.authorRubio, Mónica
dc.contributor.authorCarrillo, José María
dc.contributor.authorMartínez Subiela, Silvia
dc.contributor.authorTecles Vicente, Fernando
dc.contributor.authorCarrillo Sánchez, J. D.
dc.contributor.authorCerón Madrigal, José Joaquín
dc.contributor.departmentMedicina y Cirugía Animal
dc.contributor.otherFacultades de la UMU::Facultad de Veterinaria
dc.date.accessioned2026-03-04T09:54:08Z
dc.date.available2026-03-04T09:54:08Z
dc.date.copyright© The Author(s) 2017
dc.date.issued2017-06-09
dc.description.abstractBackground Muscle enzymes in saliva have been reported to be possible markers of heart and muscle damage in humans. The aim of this study was to assess if Creatine kinase (CK) and Aspartate aminotransferase (AST) activities could be measured in canine saliva, and to evaluate their possible changes in situations of muscle damage. Results The spectrophotometric assays for CK and AST measurement in saliva of dogs showed intra- and inter-assay imprecision lower than 1 and 16% and coefficients of correlation close to 1 in linearity under dilution tests. Healthy dogs showed activities in saliva of CK between 27 and 121 U/L and AST between 46 and 144 U/L, whereas in saliva of dogs with muscle damage CK ranged between 132 and 3862 U/L and AST between 154 and 4340 U/L. Positive moderate correlations were found between saliva and serum activities of the two enzymes (CK, r = 0.579; P = 0.001; AST, r = 0.674; P = 0.001). Conclusions CK and AST activities can be measured in canine saliva with commercially available spectrophotometric assays. In addition these enzymes show higher values in saliva of dogs with muscle damage and their values are moderately correlated with those of serum.
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dc.format.extent6
dc.identifier.citationBMC Veterinary Research (2017) 13:168
dc.identifier.doihttps://doi.org/10.1186/s12917-017-1080-x
dc.identifier.eissn1746-6148
dc.identifier.urihttp://hdl.handle.net/10201/217821
dc.languageeng
dc.publisherBioMed Central
dc.relationGERM programme of the Seneca Foundation of Murcia Region and the Garcia Cugat Foundation
dc.relation.publisherversionhttps://link.springer.com/article/10.1186/s12917-017-1080-x
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCanine
dc.subjectCreatine kinase CK
dc.subjectMuscular damage
dc.subjectSaliva
dc.subjectSerum
dc.subjectAspartate aminotransferase AST
dc.subject.odsObjetivo 4: Educación
dc.titleMeasurement of Creatine kinase and Aspartate aminotransferase in saliva of dogs: a pilot study
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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