Publication: Morphometric analyses of normal pediatric brachial biceps and quadriceps muscle tissue
Authors
Sallum, Adriana M.E. ; Varsani, Hemlata ; Holton, Janice L. ; Marie, Suely K.N. ; Wedderburn, Lucy R.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Pediatric normal brachial biceps (14
specimens) and quadriceps muscles (14 specimens) were
studied by immunohistochemistry to quantify fiber-type,
diameter and distribution, capillary density, presence of
inflammatory cells (CD3, CD20, CD68) and expression
of neonatal myosin and MHC class 1 proteins. Brachial
biceps showed more fast-twitch fibers and lower
capillary/fiber ratio than quadriceps. The mean diameter
of both fiber types was smaller in biceps than
quadriceps. Fast-fibers were smaller than slow-fibers,
and capillary/fiber ratio was <1.0 in both muscles. Fiber
size and capillary / fiber ratio increased with age.
Normal limits for infiltrating haematopoietic cells were
<4 T lymphocytes, or CD68+ cells, very few B cells, <6
neonatal myosin positive fibers, and no fibers MHC
class 1 positive in one x20 field, for both muscles. The
present comparison of quantitative findings between
brachial biceps and quadriceps may allow
standardization of the assessment of pathological
changes in both pediatric muscles.
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Citation
Histology and histopathology, Vol. 28, n.º 4 (2013)
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