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Apoptosis in gallbladder carcinomas and dysplasias, its relation to the expression of caspases 3,6 and 8 and apoptosis regulating proteins bcl-2, mcl-l and bax

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dc.contributor.authorTurunen, N.es
dc.contributor.authorPaakko, P.es
dc.contributor.authorSolni, Y.
dc.date.accessioned2011-02-22T11:20:14Z
dc.date.available2011-02-22T11:20:14Z
dc.date.issued2000
dc.description.abstractIn this study we investigated apoptosis and the expression of caspases 3, 6 and 8 and bcl-2, mcl-l and bax in 39 gallbladder carcinomas and 7 epithelia1 dysplasias. The average apoptotic index was 0.68+0.91%. The extent of apoptosis was higher in grade 11-111 than grade I tumours or epithelial dysplasias (p=0.003). Also, tumours invading beyond serosa or into other organs (T3-T4) had a higher apoptotic index than other tumours (p=0.05). Caspase 3 expression was found in 37 (95%) and caspase 6 and 8 expression each in 30 (77%) carcinomas. Their expression associated with each other and tended to increase along with the progression of the lesions. Bcl-2 expression was found in only 4 (10%) tumours. In contrast, mcl-l positivity was found in 34 (87%) and bax positivity in all cases. The results show that apoptosis is increased along with progression of the neoplastic lesion of the gallbladder epithelium. Caspases 3,6 and 8 are strongly expressed in gallbladder carcinomas suggesting that they contribute to the increased apoptosis observed in them. Of the bcl-2 family proteins, bcl-2 was expressed infrequently suggesting that it does not play any significant role in apoptosis inhibition in gallbladder tumours.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19283
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectGallbladderes
dc.subjectCarcinomaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleApoptosis in gallbladder carcinomas and dysplasias, its relation to the expression of caspases 3,6 and 8 and apoptosis regulating proteins bcl-2, mcl-l and baxes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.15, nº 1 (2000)