Publication: CXC chemokines and their receptors, A case for a significant biological role in cutaneous wound healing
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Date
2008
Authors
Zaja-Milatovic, Snjezana ; Richmond, Ann
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Wound healing requires a complex series of
reactions and interactions among cells and their
mediators, resulting in an overlapping series of events
including coagulation, inflammation, epithelialization,
formation of granulation tissue, matrix and scar
formation. Cytokines and chemokines promote
inflammation, angiogenesis, facilitate the passage of
leukocytes from circulation into the tissue, and
contribute to the regulation of epithelialization. They
integrate inflammatory events and reparative processes
that are important for modulating wound healing. Thus
both cytokines and chemokines are important targets for
therapeutic intervention.
The chemokine-mediated regulation of angiogenesis
is highly sophisticated, fine tuned, and involves proangiogenic
chemokines, including CXCL1-3, 5-8 and
their receptors, CXCR1 and CXCR2. CXCL1 and
CXCR2 are expressed in normal human epidermis and
are further induced during the wound healing process of
human burn wounds, especially during the inflammatory,
epithelialization and angiogenic processes. Human skin
explant studies also show CXCR2 is expressed in
wounded keratinocytes and Th/1/Th2 cytokine
modulation of CXCR2 expression correlates with proliferation of epidermal keratinocytes. Murine
excision wound healing, chemical burn wounds and skin
organ culture systems are valuable models for examining
the role of inflammatory cytokines and chemokines in
wound healing.
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