Publication: Muscle injuries and repair:
The role of prostaglandins and inflammation
Authors
Prisk, V. ; Huard, J.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Skeletal muscle injuries are a common
problem in trauma and orthopaedic surgery. Muscle
injuries undergo the healing phases of degeneration,
inflammation, regeneration, and fibrosis. Current and
experimental therapies to improve muscle regeneration
and limit muscle fibrosis include conservative and
surgical principles with the adjuvant use of non-steroidal
anti-inflammatory drugs (NSAIDs) and growth factor
manipulation. NSAIDs appear to have a paradoxical
effect on the healing of muscle injuries with early signs
of improvement and subsequent late impairment in
functional capacity and histology. In vitro and in vivo
studies have explored the role of the cyclooxygenases
and prostaglandins in the biological processes of healing
muscle, including precursor cell activation, myoblast
proliferation, myoblast fusion, and muscle protein
synthesis. Through use of more specific cyclooxygenase
inhibitors, we may be able to better understand the role
of inflammation in muscle healing.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.