Publication: Effects of prostaglandin Eq on the ultrastructure of the golden hamster parathyroid gland
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Date
1994
Authors
Emura, S. ; Utsumi, M. ; Hayakawa, D. ; Yamahira, T. ; Terasawa, K. ; Tamada, A. ; Isono, H. ; Shoumura, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effects of different ages on large
vacuolar bodies in the parathyroid glands of golden
hamsters after administration of prostaglandin E2
(PGE2) were investigated. In the parathyroid glands of
the young and senile animals 15 min and the senile
animals 60 min after administration of PGE2, the mean
serum calcium concentration was significantly higher
when compared to that of the young and senile control
animals, respectively. In the experimental adult animals
60 min after administration of PGE2, the serum calcium
concentration was seen to increase. In the parathyroid
glands of the young animals 15 min and the adult and
senile animals 60 min after administration of PGE2, the
percent area occupied by large vacuolar bodies was
significantly increased when compared to that of the
young, adult and senile control animals, respectively.
These findings suggest that the percent area occupied by
large vacuolar bodies is increased in response to
hypercalcemia induced by PGE2. It is thought that in the
parathyroid glands suppressed by hypercalcemia there is
a relationship between the percent area occupied by
large vacuolar bodies and aging.
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