Mechanisms underlying eosinophil
trafficking and their relevance in vivo

Cara, D. C.; Negrao-Correa, D.; Teixeira, M. M.

Publication:
Mechanisms underlying eosinophil trafficking and their relevance in vivo

dc.contributor.author	Cara, D. C.
dc.contributor.author	Negrao-Correa, D.
dc.contributor.author	Teixeira, M. M.
dc.date.accessioned	2020-07-23T12:53:59Z
dc.date.available	2020-07-23T12:53:59Z
dc.date.issued	2000
dc.description.abstract	After their formation in the bone marrow, eosinophils circulate with a short half-life and are distributed throughout the body, especially in mucosal and sub-mucosal regions. Although a small amount of these cells are normally seen in healthy tissue, blood and tissue eosinophilia is a hallmark of helminthic and allergic diseases. The role of eosinophils in the normal physiology of mucosal tissues is not understood, but there is good evidence to demonstrate that these cells protect the host at least against some intestinal helminths, specially those with a lung cycle. In addition, there are now many data that support a role for eosinophils in the pathophysiology of allergic diseases, such as asthma. Because helminthic diseases have been largely controlled in developed countries, there has been much interest in the development of drugs which affect eosinophil migration and/or activation in the tissue and which may, thus, be useful in the treatment of allergic conditions. The understanding of the mechanisms controlling eosinophil trafficking and/or activation are essential in the development of anti-eosinophil-based therapeutic strategies. The present paper reviews aspects of eosinophil biology with emphasis on the role of eosinophils in parasitic infections and allergy, the basic mechanisms underlying the trafficking of eosinophils into tissue and how these can be modulated pharmacologically.	es
dc.format	application/pdf	es
dc.format.extent	22	es
dc.identifier.citation	Histology and Histopathology, Vol. 15, n.º 3 (2000)
dc.identifier.issn	1699-5848
dc.identifier.issn	0213-3911
dc.identifier.uri	http://hdl.handle.net/10201/95172
dc.language	eng	es
dc.publisher	F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Eosinophil	es
dc.subject	Allergy	es
dc.subject	Helminths	es
dc.subject	Trafficking	es
dc.subject	Interleukin-5	es
dc.subject	Cell adhesion molecules	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología	es
dc.title	Mechanisms underlying eosinophil trafficking and their relevance in vivo	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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