Publication: Cell rounding with «Rip off» detachment
Authors
Sit, K.H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The «rounding up» characteristic of mitotic,
apoptotic, transformed and non-transformed cells
appears to be initiated by various causative factors.
Cytoskeletal and adhesion modulations have been
implicated. Endocytic intemalization via large channels
seen in the rounding of arnoeba and human cells alike,
implicate a third mechanism, viz. membrane flow and
fusion, where «rip off» detachment sheds parts of the
cell to achieve freedom. Mutilation as a means for
detachment is also used by moving fibroblasts, linking
shape change with movement via a distinct mechanism.
While rounding may follow detachment and detachment
may follow rounding, «rip off» mutilation, whether selfinflicted
or imposed, and modulation of stickiness are
fundamentally different processes
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Citation
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