Publication:
Expression of amine oxidase-related proteins in breast phyllodes tumor

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Kim-40-39-47-2025.pdf(1.64 MB)
Date
2025
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Authors
Kim, Hye Min ; Koo, Ja Seung
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-773
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info:eu-repo/semantics/article
Description
Abstract
Background. Breast phyllodes tumors (BPTs) are difficult to differentiate from other tumor types. In-depth research is needed due to the insufficient description of the amine oxidase protein family, particularly in BPTs. Objective. This study investigated the expression and clinical implications of amine oxidase-related proteins in BPTs. METHODS: Tissue microarrays were constructed (n=181), and amine oxidase-related proteins of monoamine oxidase (MAO) A, MAOB, lysyl oxidase (LOX), and primary-amine oxidase 3 (AOC3) were assessed using immunohistochemical staining. Staining patterns of these proteins were compared and analyzed with clinicopathologic parameters. Results. In all, 149, 27, and 5 cases were classified as benign, borderline, and malignant, respectively. A higher grade of BPT was associated with increased MAOB (P<0.001), LOX (P=0.035), and AOC3 (P<0.001) expression. BPT cases with tumor recurrence and distant metastasis had higher proportions of MAOB positivity in stromal components (P=0.002 and 0.018, respectively). During follow-up, there was a significant association between MAOB positivity in the stromal component and shorter disease-free survival (DFS) (P=0.001) as well as overall survival (P=0.003). Moreover, MAOB positivity emerged as an independent factor for shorter DFS (hazard ratio: 4.253, 95% confidence interval: 1.034–17.49, P=0.045). Conclusions. Higher MAOB, LOX, and AOC3 expression were observed in higher-grade BPTs, and MAOB expression was identified as a significant prognostic factor.
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Amine oxidase , Breast , Phyllodes tumor , Monoamine oxidase B
Citation
Histology and Histopathology Vol. 40, nº01 (2025)
URI
http://hdl.handle.net/10201/148022
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Histology and histopathology Vol.40, nº1 (2025)
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