Publication: Prognostic value of p53 protein expression and
clinicopathological factors in infiltrating ductal
carcinoma of the breast. A study of 192 patients
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Date
2001
Authors
Sirvent, J. J. ; Fortuño Mar, A. ; Olana, M. ; Ortí, A.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The p53 gene is located on the short arm of
chromosome 17. It encodes a 53-kd nuclear protein
(p53) found in scant amounts in normal tissue.
Mutations of the p53 gene have been reported in
different human tumours. In breast cancer, it has been
noted that the overexpression of p53 protein in the
nucleus is an indicator of poor prognosis, although there
is a high degree of variability, which may be due to
different immunohistochemical techniques, varying
assessment of results a nd the type of monoclonal
antibody used.
This study is an immunohistochemical analysis of
p53 expression in 192 cases of infiltrating ductal
carcinoma of the breast, correlating it with
clinicopathological factors and the clinical course of the
disease.
Of all the breast-cancer tissue analysed, stains for
p53 antibody were found in 87 tumours (45.3%). The
results of multivariate ana lysis show that the independent
predictors related to recurrence are tumour size, Iymphnode metastasis and p53, while those related to death are
necrosis, lymph-node metastasis and p53.
In summary, our series showed prognostic
significance between the expression of p53 and shorter
survival time and disease-free interval for all patients in
general as well as those who prese nted lymph-node
metastases at the time of diagnosis.
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Citation
Histology and Histopathology, Vol. 16, n.º 1 (2001)
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