Extracellular vesicles in seminal fluid and effects on male reproduction. An overview in farm animals and pets

Roca Aleu, Jorge; Rodríguez Martínez, Heriberto; Padilla, Lorena; Lucas, Xiomara; Barranco Cascales, Isabel

Publication:
Extracellular vesicles in seminal fluid and effects on male reproduction. An overview in farm animals and pets

dc.contributor.author	Roca Aleu, Jorge
dc.contributor.author	Rodríguez Martínez, Heriberto
dc.contributor.author	Padilla, Lorena
dc.contributor.author	Lucas, Xiomara
dc.contributor.author	Barranco Cascales, Isabel
dc.contributor.department	Medicina y Cirugía Animal
dc.date.accessioned	2025-10-17T10:03:00Z
dc.date.available	2025-10-17T10:03:00Z
dc.date.copyright	© 2021 Elsevier B.V.
dc.date.issued	2022-11
dc.description.abstract	Extracellular vesicles (EVs) are lipid bilayer nanovesicles released by most functional cells to body fluids, containing bioactive molecules, mainly proteins, lipids, and nucleic acids having actions at target cells. The EVs have essential functions in cell-to-cell communication by regulating different biological processes in target cells. Fluids from the male reproductive tract, including seminal plasma, contain many extracellular vesicles (sEVs), which have been evaluated to a lesser extent than those of other body fluids, particularly in farm animals and pets. Results from the few studies that have been conducted indicated epithelial cells of the testis, epididymis, ampulla of ductus deferens and many accessory sex glands release sEVs mainly via apocrine mechanisms. The sEVs are morphologically heterogeneous and bind to functional cells of the male reproductive tract, spermatozoa, and cells of the functional tissues of the female reproductive tract after mating or insemination. The sEVs encapsulate proteins and miRNAs that modulate sperm functions and male fertility. The sEVs, therefore, could be important as reproductive biomarkers in breeding sires. Many of the current findings regarding sEV functions, however, need experimental confirmation. Further studies are particularly needed to characterize both membranes and contents of sEVs, as well as the interaction between sEVs and target cells (spermatozoa and functional cells of the internal female reproductive tract). A priority for conducting these studies is development of methods that can be standardized and that are scalable, cost-effective and time-saving for isolation of different subtypes of EVs present in the entire population of sEVs.
dc.format	application/pdf
dc.format.extent	15
dc.identifier.citation	Animal Reproduction Science, 2022, Vol. 246 : 106853
dc.identifier.doi	https://doi.org/10.1016/j.anireprosci.2021.106853
dc.identifier.eissn	1873-2232
dc.identifier.issn	0378-4320
dc.identifier.uri	http://hdl.handle.net/10201/167449
dc.language	eng
dc.relation	The research of the authors was funded by Ministerio de Ciencia e Innovacion and European Regional Development Fund (Grant PID2020-113493RB-I00), Madrid, Spain; the Swedish Research Council (FORMAS) (Grants 2017-00946 and 2019-00288), Stockholm, Sweden and European Union's Horizon 2020 research and innovation program (Grant H2020-MSCA-IF-2019-891382).
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0378432021001688
dc.rights.accessRights	info:eu-repo/semantics/restrictedAccess
dc.subject	Accessory sex glands
dc.subject	Epididymis
dc.subject	Extracellular vesicles
dc.subject	Livestock species
dc.subject	Pets
dc.subject	Seminal plasma
dc.subject.ods	No relacionado con ningún objetivo de desarrollo sostenible
dc.title	Extracellular vesicles in seminal fluid and effects on male reproduction. An overview in farm animals and pets
dc.type	info:eu-repo/semantics/article
dspace.entity.type	Publication	es
relation.isAuthorOfPublication	032b17bf-c6a7-4745-a513-c02b384cc26c
relation.isAuthorOfPublication	3c34d0d5-7d7d-4bcc-a119-8906f53baa7b
relation.isAuthorOfPublication.latestForDiscovery	032b17bf-c6a7-4745-a513-c02b384cc26c