Publication: Evaluation of the smooth muscle cell eomponent and apoptosis in the varicose vein wall
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Date
2000
Authors
Buján, J. ; Jimenez-Cossio, J.A. ; Jurado, F. ; Gimeno, M.J. ; Pascual, G. ; García-Honduvilla, N. ; Dominguez, B. ; Bellón, J.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This study was designed to evaluate the role
of the smooth muscle cell and the apoptosis in the
pathogenesis of the varicose vein.
Segments of saphenous vein were obtained from
healthy subjects and from those with varicose veins. The
vein specimens were subdivided according to subject
age (younger or older than 50 years) and according to
the varicose vein source (distal or proximal).
Morphological, ultrastructural, cell proliferation (anti-
PCNA method) and cell death (TUNEL method)
analysis were performed.
The walls of healthy, control vein specimens
acquired a more collagenous and papilomatous
appearance with age. A slight increase in the number of
TUNEL-positive cells was also observed in specimens
from older subjects. The proportion of apoptotic cells
was much greater in the varicose veins than in control
specimens. Most cellular alterations were seen in
proximal varicose segments obtained from young
subjects. These specimens showed hypertrophic areas
with a high degree of cellularity (both in the media and
in the thickened intima). The highest proportion of
apoptotic cells and collagenisation were also observed in
these areas. The enhanced number of apoptotic cells in
varicose veins observed mainly in proximal/young vein
specimens could be responsible, at least in part, for the
acceleration of the final fibrosclerotic process
characteristic of the varicose vein wall.
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