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The history and histology of bone morphogenetic protein

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dc.contributor.authorMurray, Samuel S.
dc.contributor.authorBrochmann Murray, Elsa J. B
dc.contributor.authorWang, Jeffrey C.
dc.contributor.authorLeite Duarte, Maria Eugenia
dc.date.accessioned2021-07-27T11:30:11Z
dc.date.available2021-07-27T11:30:11Z
dc.date.issued2016
dc.description.abstractBone morphogenetic proteins are a group of structurally related proteins within the TGF-β superfamily of proteins with a diverse repertoire of functions in embryonic and adult organisms. As is apparent from the name, the members first characterized participate in bone growth, development, and remodeling. The “morphogenic” activity per se is defined as the induction of a recapitulation of endochondral bone formation by appropriate stem cells. The regenerative capacity of bone has been recognized since ancient times. The mechanism, applications, and conceptual basis of bone transplantation, bone implantation, ectopic bone formation, and exogenously induced bone formation have been studied by many investigators for more than a century. This review examines the efforts to characterize this activity in the European and American literature over approximately the last century. Because of the inherently complex nature of the process induced by these molecules (inflammation, stem cell proliferation, cartilage differentiation, replacement of cartilage with bone) it is important to evaluate previous investigations through a histological perspective. The cellular basis of the contemporary bioassay for BMP activity is illustrated and discussed from the histological point of view.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and histopathology: Vol.31, nº7 (2016)
dc.identifier.doiDOI: 10.14670/HH-11-774
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/111383
dc.languageenges
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBone morphogenetic proteines
dc.subjectBonees
dc.subjectEndochondral bone formationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleThe history and histology of bone morphogenetic proteines
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.31, nº7 (2016)