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Cytokine profiles in cord blood in relation to prenatal traffic-related air pollution: The NELA cohort

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dc.contributor.authorGarcía-Serna, Azahara M
dc.contributor.authorJiménez-Guerrero, Pedro
dc.contributor.authorPérez-Fernández, Virginia
dc.contributor.authorCantero-Cano, Esther
dc.contributor.authorMuñoz-García, María
dc.contributor.authorMolina-Ruano, María Dolores
dc.contributor.authorRojo-Atenza, Encarna
dc.contributor.authorGarcía-Marcos, Luis
dc.contributor.authorMorales, Eva
dc.contributor.authorHernández Caselles, Trinidad
dc.contributor.authorMartín-Orozco Santiago, María Elena
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.date.accessioned2024-01-28T14:14:29Z
dc.date.available2024-01-28T14:14:29Z
dc.date.issued2022-02-18
dc.description©2022.This document is the Published, version of a Published Work that appeared in final form in Pediatric Allergy and Immunology (PAI). To access the final edited and published work see https://doi.org/10.1111/pai.13732es
dc.description.abstractBackground: Outdoor air pollution may disturb immune system development. We investigated whether gestational exposure to traffic-related air pollutants (TRAP) is associated with unstimulated cytokine profiles in newborns. Methods: Data come from 235 newborns of the NELA cohort. Innate response-related cytokines (IL-6, IFN-α, IL1-β, and TNF-α), Th1-related (IFN-γ and IL-2), Th2-related (IL-4, IL-5, and IL-13), Th17-related (IL-17 and IL-23), and immunomodulatory cytokine IL-10 were quantified in the supernatant of unstimulated whole umbilical cord blood cells after 7 days of culture using the Luminex technology. Dispersion/chemical transport modeling was used to estimate long-term (whole pregnancy and trimesters) and short-term (15 days before delivery) residential exposures to traffic-related nitrogen dioxide (NO2 ), particulate matter (PM2.5 and PM10 ), and ozone (O3 ). We fitted multivariable logistic regression, Bayesian kernel machine regression (BKMR), and weighted quantile sum (WQS) regression models. Results: NO2 during the whole pregnancy increased the odds of detection of IL-1β (OR per 10 µg/m3 increase = 1.37; 95% CI, 1.02, 1.85) and IL-6 (OR per 10 µg/m3 increase = 1.32; 95% CI 1.00, 1.75). Increased odds of detected concentrations of IL-10 was found in newborns exposed during whole pregnancy to higher levels of NO2 (OR per 10 µg/m3 increase = 1.30; 95% CI 0.99, 1.69), PM10 (OR per 10 µg/m3 increase = 1.49; 95% CI 0.95, 2.33), and PM2.5 (OR per 5 µg/m3 increase = 1.56; 95% CI 0.97, 2.51). Exposure to O3 during the whole pregnancy increased the odds of detected IL-13 (OR per 10 µg/m3 increase = 1.22; 95% CI 1.01, 1.49). WQS model revealed first and third trimesters of gestation as windows of higher susceptibility. Conclusions: Gestational exposure to TRAP may increase detection of pro-inflammatory, Th2-related, and T regulatory cytokines in newborns. These changes might influence immune system responses later in life.es
dc.embargo.terms1-ene-2999
dc.formatapplication/pdfes
dc.format.extent13es
dc.identifier.citationPediatric Allergy and Immunology (PAI). 2022 Feb 33(2):e13732.
dc.identifier.doidoi: 10.1111/pai.13732
dc.identifier.issn1399-3038
dc.identifier.issn0905-6157
dc.identifier.urihttp://hdl.handle.net/10201/137887
dc.languageenges
dc.relationThis study was supported by grants from Instituto de Salud Carlos III, Spanish Ministry of Science, Innovation and Universities, and Fondos FEDER (grant numbers CP14/00046, PIE15/00051, PI16/00422, PI19/00863 and ARADyAL network RD160006). A.M.G.S. was funded by a predoctoral fellowship (FI17/00086) and E.M. was funded by Miguel Servet grants (MS14/00046 and CPII19/00019) awarded by the Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Science, Innovation and Universities, and Fondos FEDER.es
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAir pollutiones
dc.subjectBirth cohortes
dc.subjectCord bloodes
dc.subjectCytokineses
dc.subjectTraffices
dc.titleCytokine profiles in cord blood in relation to prenatal traffic-related air pollution: The NELA cohortes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationc0416b92-3bd1-4c0a-bd7c-df5ae58f3f63
relation.isAuthorOfPublication24de46e8-df34-4c71-a701-2a30b079b958
relation.isAuthorOfPublication.latestForDiscoveryc0416b92-3bd1-4c0a-bd7c-df5ae58f3f63
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