Publication:
Age‑dependent association of clonal hematopoiesis with COVID‑19 mortality in patients over 60 years

Simple item page
dc.contributor.authorDel Pozo‑Valero, Marta
dc.contributor.authorCorton, Marta
dc.contributor.authorLópez‑Rodríguez, Rosario
dc.contributor.authorMahillo‑Fernández, Ignacio
dc.contributor.authorRuiz‑Hornillos, Javier
dc.contributor.authorMinguez, Pablo
dc.contributor.authorVillaverde, Cristina
dc.contributor.authorPérez‑Tomás, María Elena
dc.contributor.authorBarreda‑Sánchez, María
dc.contributor.authorMancebo, Esther
dc.contributor.authorSTOP_Coronavirus Study Group
dc.contributor.authorPaz‑Artal, Estela
dc.contributor.authorGuillén‑Navarro, Encarna
dc.contributor.authorAlmoguera, Berta
dc.contributor.authorAyuso, Carmen
dc.contributor.authorGarcía-Vázquez, Elisa
dc.contributor.departmentMedicina
dc.date.accessioned2024-06-28T07:45:24Z
dc.date.available2024-06-28T07:45:24Z
dc.date.issued2022-10-03
dc.description©2022 This document is the SPublished, version of a Published Work that appeared in final form in GeroScience . To access the final edited and published work see https://doi.org/10.1007/s11357-022-00666-5es
dc.description.abstractClonal hematopoiesis, especially that of indeterminate potential (CHIP), has been associated with age-related diseases, such as those contributing to a more severe COVID-19. Four studies have attempted to associate CHIP with COVID-19 severity without conclusive findings. In the present work, we explore the association between CHIP and COVID-19 mortality. Genomic DNA extracted from peripheral blood of COVID-19 patients (n = 241 deceased, n = 239 survivors) was sequenced with the Myeloid Solutions™ panel of SOPHiA Genetics. The association between clonality and age and clonality and mortality was studied using logistic regression models adjusted for sex, ethnicity, and comorbidities. The association with mortality was performed with patients stratified into four groups of age according to the quartiles of the distribution: 60–74 years, 75–84 years, 85–91 years, and 92–101 years. Clonality was found in 38% of the cohort. The presence of CHIP variants, but not the number, significantly increased with age in the entire cohort of COVID-19 patients, as well as in the group of survivors (p < 0.001). When patients were stratified by age and the analysis adjusted, CHIP classified as pathogenic/likely pathogenic was significantly more represented in deceased patients compared with survivors in the group of 75–84 years (34.6% vs 13.7%, p = 0.020). We confirmed the well-established linear relationship between age and clonality in the cohort of COVID-19 patients and found a significant association between pathogenic/likely pathogenic CHIP and mortality in patients from 75 to 84 years that needs to be further validated.es
dc.embargo.terms1-ene-2999
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationGeroScience (2023) 45(1):543–553
dc.identifier.doihttps://doi.org/10.1007/s11357-022-00666-5
dc.identifier.issnPrint: 2509-2715
dc.identifier.issnElectronic: 2509-2723
dc.identifier.urihttp://hdl.handle.net/10201/142749
dc.languageenges
dc.publisherSpringeres
dc.relationInstituto de Salud Carlos III (PT20/00141); BIOBANC-MUR; IMIB-Arrixaca and Consejería de Salud de la Región de Murcia (CARM).es
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCOVID-19es
dc.subjectMortality riskes
dc.subjectClonal variantses
dc.titleAge‑dependent association of clonal hematopoiesis with COVID‑19 mortality in patients over 60 yearses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Age‑dependent association of clonal hematopoiesis....pdf
Size:
1.01 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.26 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos