Publication: Effect of endurance running on cardiac and skeletal muscle in rats
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Date
2001
Authors
Díaz-Herrera, P. ; Torres, A. ; Morcuende, J.A. ; Garcia-Castellano, J.M. ; Calbet, J.A.L. ; Sarrat, R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We studied the effect of resistance running
on left cardiac ventricle size and rectus femoris muscle
fiber composition. Ten male Wistar rats were trained on
a treadmill 6 days per week for 12 weeks. Ten rats
remained sedentary and served as controls. A higher
endurance time (40%) and cardiac hypertrophy in the
trained animals were indicators of training efficiency.
Morphometric analysis of the left ventricle crosssectional
area, left ventricular wall, and left ventricular
cavity were evaluated. The endurance-running group
demonstrated a hypertrophy of the ventricular wall
(22%) and an increase in the ventricular cavity (25%);
(pc0.0001). Semi-quantitative analysis of rectus femoris
fiber-type composition and of the oxidative and
glycolytic capacity was histochemically performed.
Endurance running demonstrated a significant (pc0.01)
increase in the relative frequency of 5 p e 1 (24%), Qpe
IIA (8%) and 5 p e IIX (16%) oxidative fibers, and a
decrease in Qpe IIB (20%) glycolytic fibers. There was
a hypertrophy of both oxidative and glycolytic fiber
types. The relative cross-sectional area analysis
demonstrated an increase in oxidative fibers and a
decrease in glycolytic fibers (p<0.0001). Changes were
especially evident for 'Qpe IIX oxidative-glycolytic
fibers. The results of this study indicate that the left
ventricle adapts to endurance running by increasing wall
thickness and enlargement of the ventricular cavity.
Skeletal muscle adapts to training by increasing oxidative fiber 'Qpe. This increase may be related to
fiber transformation from Qpe IIB glycolytic to Qpe
IIX oxidative fibers. These results open the possibility
for the use of this type of exercise to prevent muscular
atrophy associated with age or post-immobilization.
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