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Changes in the neuronal activity in the pedunculopontine nucleus in chronic MPTP-treated primates: an in situ hybridization study of cytochrome oxidase subunit I, choline acetyl transferase and substance P mRNA expression

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dc.contributor.authorFernández Villalba, Emiliano
dc.contributor.authorFernández Barreiro, Andrés
dc.contributor.authorHerrero Ezquerro, María Trinidad
dc.contributor.authorGómez Gallego, María
dc.contributor.departmentAtención Sociosanitaria
dc.date.accessioned2024-07-26T10:29:46Z
dc.date.available2024-07-26T10:29:46Z
dc.date.issued2007-03
dc.description© Springer-Verlag 2006. This document is the Published version of a Published Work that appeared in final form in Journal of Neural Transmission. To access the final edited and published work see https://doi.org/10.1007/s00702-006-0547-x
dc.description.abstractSummary. The pedunculopontine nucleus is a mesencephalic nucleus that has widespread and reciprocal connections with the basal ganglia. It has been implicated in the physiopathology of akinesia, rigidity, gait failure and sleep disorders associated with Parkinson’s disease. In this study, in situ hybridization was used to examine the changes in neuronal metabolic activity (measuring cytochrome oxidase subunit I) and in the level of acetylcholine and Substance P synthesis in the pedunculopontine nucleus of monkeys chronically treated with MPTP. Significant reductions were observed in cytochrome oxidase subunit I (p = 0.001), choline acetyl transferase (p = 0.003) and substance P (p = 0.006) mRNA expression in parkinsonian animals compared with controls, indicating that pedunculopontine cholinergic neurons activity decreases with parkinsonism.es
dc.embargo.terms1-ene-2999
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationJournal of Neural Transmission, 2007, 2007, Vol. 114, pp. 319–326
dc.identifier.doihttps://doi.org/10.1007/s00702-006-0547-x
dc.identifier.issnPrint: 0300-9564
dc.identifier.issnElectronic: 1435-1463
dc.identifier.urihttp://hdl.handle.net/10201/143399
dc.languageenges
dc.publisherSpringeres
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00702-006-0547-x
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectParkinsonismes
dc.subjectCytochrome oxidase Ies
dc.subjectCholine acetyl transferasees
dc.subjectSubstance Pes
dc.subjectIn situ hybridizationes
dc.subjectPrimateses
dc.titleChanges in the neuronal activity in the pedunculopontine nucleus in chronic MPTP-treated primates: an in situ hybridization study of cytochrome oxidase subunit I, choline acetyl transferase and substance P mRNA expressiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication9bbe7af5-429b-4029-b621-0399a6838322
relation.isAuthorOfPublication44278cfb-f559-47b0-950d-fdecaf73adf3
relation.isAuthorOfPublication.latestForDiscovery9bbe7af5-429b-4029-b621-0399a6838322
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