Publication: Mortalin: a potential candidate for biotechnology and biomedicine
Authors
Wadhwa, R. ; Taira, K. ; Kaul, S.C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Mortalin is a novel member of the hsp70
family of proteins that exhibits a different staining
pattern in normal and immortal cells. It was also cloned
as glucose regulated protein, GRP75 and peptidebinding
protein, PBP74. It has been assigned multiple
functions ranging from stress response, intracellular
trafficking, antigen processing, control of cell
proliferation, differentiation and tumorigenesis. The
present article compiles and reviews information on
multiple sites and functions of mortalin. In view of its
upregulation in many tumors and transcriptional
inactivation function of p53, its potential use in
biotechnology and biomedicine is discussed
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Citation
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