Publication: Paravertebral muscles in experimental scoliosis, a light and electron microscopic study
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Date
1998
Authors
Garrosa, M. ; Fernández-Mariño, J.R. ; Gayoso Rodriguez, Manuel J. ; Tomey, M.J. ; Al-Majdalawi, A. ; Rodríguez, L.P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Experimental! structural dextroconvex
scoliosis was produced in rabbits by costotransversolisis
with transversectomy and releasing of paravertebral
muscles between TVII and TX on the right side. Two
compensatory curves developed on the upper dorsal and
lumbar levels. Biopsies of paravertebral muscles in
experimental animals included, besides areas of normal
tissue, a considerable derangement of the cell contractile
apparatus with sarcoplasmic dilation and eventual cell
disintegration and necrosis. Histological changes varied
along levels, the convexit!~ being more affected. The
severity of changes and retiuction in body weight and
length were correlated with the degree of scoliosis. A
selective atrophy of slow-twitch fibers was observed in
experimental animals, especially at the level of the main
curve, whereas fast-twitch fiber atrophy was more
important caudally. Control animal biopsies always
appeared normal. Our experimental model shows an
overt participation of paravertebral muscles in the
establishment of compens,atory processes following
scoliosis, although the role that paravertebral muscles
play in the etiopathogenesis of human idiopathic
scoliosis requires further investigation.
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