Publication: Molecular genetics of ovarian carcinomas
Authors
Diebold, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The phenotypic variability of epithelial
ovarian neoplasms correlates with a diversity of changes
at the molecular level. Invasive serous and undifferentiated
ovarian carcinomas are characterized by
p53 mutations with p53 protein accumulation, extensive
loss of genetic material of chromosome 17 and complex
changes on many other chromosomes, e.g. amplification
of oncogenes. These alterations are seen only in a
minority of mucinous and endometrioid carcinomas,
mainly in advanced stages. Overexpression of bcl-2 is
seen most frequently in endometrioid carcinomas (ca.
90% of cases), which in addition show microsatellite
instability in around a third of the cases, as has been
described in endometrioid endometrial carcinomas.
KRAS mutations are characteristic for mucinous LMP
tumors and mucinous carcinomas (40-50% of cases) and
are also found in a third of serous LMP tumors. In
addition, serous LMP tumors show mild microsatellite
instability in 30%. However, complex chromosomal
aberrations are never seen in these neoplasms
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Citation
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