Publication: Liver cell dysplasia: reactivities for c-met protein, Rb protein E-cadherin and transforming growth
factor-01 in comparison with hepatocellular carcinoma
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Date
1998
Authors
Zhao, M. ; Zimmermann, Astrid
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In the present retrospective study, liver cell
dysplasia (LCD) occurring in cirrhotic livers associated
or not associated with hepatocellular carcinoma (HCC)
was immunohistochemically analyzed for the expression
of hepatocyte growth factor receptor (c-met protein), Rb
(retinoblastoma gene) protein, E-cadherin, and transforming
growth factor-B-l (TGF-B-1). Cytoplasmic cmet
protein staining was observed in about half of the
HCC's, and its prevalence was about twice as high in
high grade vs. low grade tumors, but it was not
correlated with proliferative activity as based on PCNA
labelling. In LCD, reactivity for c-met protein was
restricted to the small cell type. Nuclear staining for Rb
protein was found in HCC's, and was not related to type,
grade or proliferative activity, whereas no immunoreactivity
was observed in normal, hyperplastic or
dysplastic hepatocytes. Expression of E-cadherin
prevailed in HCC's of lower grade, and particularly in
those with a trabecular or acinar growth pattern. Ecadherin
staining was detectable in normal and large
dysplastic hepatocytes, but not in small dysplastic liver
cells. TGF-B-1 reactivity was observed in more than half
the HCC's, but not in normal or dysplastic hepatocytes.
These findings underline the phenotypic difference
between large cell and small cell liver dysplasia, and
support the hypothesis that small cell dysplasia is a
precursor lesion in a hepatocarcinogenic pathway.
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