Publication: Exploring the connection between chronic renal fibrosis and bone morphogenic protein-7
Authors
Kalluri, R. ; Zeisberg, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Tubulointerstitial fibrosis is a hallmark
feature of chronic renal injury. Specific therapies to
control the progression of renal fibrosis towards endstage
renal failure are still limited. Transforming growth
factor-ß1 (TGF-ß1) has been identified as a major
mediator of renal fibrosis. Recent reports have suggested
that Bone Morphogenic Protein-7 (BMP-7), another
member of the TGF-ß superfamily, accelerates repair of
acute renal injury and ameliorates progression of chronic
renal fibrosis in a variety of animal models.
Interestingly, BMP-7, an endogenous molecule which is
present in the normal kidney, vastly decreases its
expression during renal injury. Although, the mechanism
of BMP-7 action in the kidney is not yet fully
understood, the idea of an endogenous molecule with
reno-protective function is intriguing
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Citation
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