Effect of antibiotics and NSAIDs on cyclooxygenase-2 in the enamel mineralization

Serna Muñoz, Clara; Pérez Silva, Amparo; Solano, Francisco; Castells Mora, María Teresa; Vicente, Ascensión; Ortiz Ruiz, Antonio José

Publication:
Effect of antibiotics and NSAIDs on cyclooxygenase-2 in the enamel mineralization

dc.contributor.author	Serna Muñoz, Clara
dc.contributor.author	Pérez Silva, Amparo
dc.contributor.author	Solano, Francisco
dc.contributor.author	Castells Mora, María Teresa
dc.contributor.author	Vicente, Ascensión
dc.contributor.author	Ortiz Ruiz, Antonio José
dc.contributor.department	Dermatología, Estomatología, Radiología y Medicina Física
dc.date.accessioned	2024-06-21T10:32:15Z
dc.date.available	2024-06-21T10:32:15Z
dc.date.issued	2018-03-07
dc.description	© The Author(s) 2018. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Scientific Reports. To access the final edited and published work see https://doi.org/10.1038/s41598-018-22607-z
dc.description.abstract	The objective of this study was to determine whether the use of the most commonly prescribed antibiotics and non-steroidal anti-inflammatory drugs in childhood could disturb enamel mineralization. Forty-two Swiss mice were divided into seven groups: controls; amoxicillin; amoxicillin/clavulanate; erythromycin; acetaminophen; ibuprofen and celecoxib, to inhibit cyclooxygenase 2 (COX2). SEM-EDX analysis was conducted on all cusps of the third molars. Calcium (Ca), phosphorus (P), aluminum, potassium, sodium, magnesium and chlorine were quantified. The stoichiometric Ca/P molar ratios were calculated. Immunohistochemical quantification of COX2 in incisors was carried out by image analysis using COX2-specific immunostaining. Groups treated with antibiotics showed no significant differences in the content of the chemical elements. Only acetaminophen and celecoxib showed a significant decrease in Ca and P compared with the control samples. Ca/P ratios showed no difference. Groups treated with amoxicillin, amoxicillin/clavulanate, erythromycin and acetaminophen showed significantly lower amounts of immunoreactive COX2 at the enamel organ maturation stage of the mouse incisors. Our results suggest that COX2 is involved in the maturation stage of the enamel organ and that its inhibition would appear to alter amelogenesis, producing hypomineralization.	es
dc.format	application/pdf	es
dc.format.extent	7	es
dc.identifier.citation	Scientific Reports, 8(1): 4132 (2018)
dc.identifier.doi	https.//doi.org/10.1038/s41598-018-22607-z
dc.identifier.issn	Electronic: 2045-2322
dc.identifier.uri	http://hdl.handle.net/10201/142536
dc.language	eng	es
dc.publisher	Nature Research	es
dc.relation	Sin financiación externa a la Universidad	es
dc.relation.publisherversion	https://www.nature.com/articles/s41598-018-22607-z
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.title	Effect of antibiotics and NSAIDs on cyclooxygenase-2 in the enamel mineralization	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
relation.isAuthorOfPublication	8f2b9ceb-be71-4257-a82d-eba42a375885
relation.isAuthorOfPublication	d6ad2235-d5ca-4574-85eb-964da3c5c44c
relation.isAuthorOfPublication	d6ad2235-d5ca-4574-85eb-964da3c5c44c
relation.isAuthorOfPublication.latestForDiscovery	8f2b9ceb-be71-4257-a82d-eba42a375885