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All that glitters in cfDNA analysis is not gold or its utility is completely established due to graft damage: a critical review in the field of transplantation

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dc.contributor.authorJiménez Coll, Víctor
dc.contributor.authorEl kaaoui El band, Jaouad
dc.contributor.authorLlorente, Santiago
dc.contributor.authorGonzález López, Rosana
dc.contributor.authorFernández González, Marina
dc.contributor.authorMartínez Banaclocha, Helios
dc.contributor.authorGalián, José Antonio
dc.contributor.authorBotella, Carmen
dc.contributor.authorMoya Quiles, María Rosa
dc.contributor.authorMinguela, Alfredo
dc.contributor.authorMuro, Manuel
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-08T11:28:58Z
dc.date.available2024-07-08T11:28:58Z
dc.date.issued2023-06-06
dc.description© 2023 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published version of a Published Work that appeared in final form in Diagnostics. To access the final edited and published work see https://doi.org/10.3390/diagnostics13121982
dc.description.abstractIn kidney transplantation, a biopsy is currently the gold standard for monitoring the transplanted organ. However, this is far from an ideal screening method given its invasive nature and the discomfort it can cause the patient. Large-scale studies in renal transplantation show that approximately 1% of biopsies generate major complications, with a risk of macroscopic hematuria greater than 3.5%. It would not be until 2011 that a method to detect donor-derived cell-free DNA (dd-cfDNA) employing digital PCR was devised based on analyzing the differences in SNPs between the donor and recipient. In addition, since the initial validation studies were carried out at the specific moments in which rejection was suspected, there is still not a good understanding of how dd-cfDNA levels naturally evolve post-transplant. In addition, various factors, both in the recipient and the donor, can influence dd-cfDNA levels and cause increases in the levels of dd-cfDNA themselves without suspicion of rejection. All that glitters in this technology is not gold; therefore, in this article, we discuss the current state of clinical studies, the benefits, and disadvantages.es
dc.formatapplication/pdfes
dc.format.extent13es
dc.identifier.citationDiagnostics 2023, 13 (12), 1982
dc.identifier.doihttps://doi.org/10.3390/diagnostics13121982
dc.identifier.issnElectronic: 2075-4418
dc.identifier.urihttp://hdl.handle.net/10201/142929
dc.languageenges
dc.publisherMDPI
dc.relationOur work was possible thanks to support from Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness. Grant Number P19/01194 and co-funding of the European Union with European Fund of Regional Development (FEDER) with the principle of “A manner to build Europe”.es
dc.relation.publisherversionhttps://www.mdpi.com/2075-4418/13/12/1982
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDonor-derived cell-free DNA (cfDNA)es
dc.subjectGraft injuryes
dc.subjectAcute rejectiones
dc.subjectOrgan transplantes
dc.subjectMonitoringes
dc.titleAll that glitters in cfDNA analysis is not gold or its utility is completely established due to graft damage: a critical review in the field of transplantationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoveryb83b4b59-2d61-40f0-9108-5c6a6d158295
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