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Biotechnological approach to increase oxyresveratrol production in mulberry in vitro plants under elicitation

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dc.contributor.authorNicolás Sánchez, Isabel
dc.contributor.authorAlmagro Romero, Lorena
dc.contributor.authorPedreño García, María Ángeles
dc.contributor.authorSabater Jara, Ana Belén
dc.contributor.departmentBiología Vegetal
dc.date.accessioned2025-05-16T12:04:09Z
dc.date.available2025-05-16T12:04:09Z
dc.date.issued2023-01-25
dc.description© 2023 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in Plants. To access the final edited and published work see https://doi.org/10.3390/plants12030546
dc.description.abstractMorus alba L. is used for a range of therapeutic purposes in Asian traditional medicine, and its extracts are reported to be effective against lipidemia, diabetes, and obesity, as well as being hepatoprotective and tyrosinase-inhibitory. They are also included in cosmetic products as anti-aging and skin-whitening agents. Stilbenes, the major bioactive compounds found in M. alba, have received renewed attention recently because of their putative activity against COVID-19. In this study M. alba plants were established in vitro, and the effect of elicitation on plant growth and stilbene accumulation, specifically oxyresveratrol and trans-resveratrol, was investigated. Different concentrations of the elicitors including methyl jasmonate and cyclodextrins were applied, and stilbene levels were determined in leaves, roots, and the culture medium. Elicitation of the M. alba plants with 5 mM cyclodextrins, alone or in combination with 10 µM methyl jasmonate, significantly increased the total phenolic content in the culture medium and leaves after 7 days of treatment. The higher total phenolic content in the roots of control plants and those treated only with methyl jasmonate indicated that cyclodextrins promoted metabolite release to the culture medium. Notably, the cyclodextrin-treated plants with the highest levels of oxy- and trans-resveratrol also had the highest total phenolic content and antioxidant capacity. These results indicate that elicited M. alba in vitro plants constitute a promising alternative source of bioactive stilbenes to supply pharmaceutical and cosmeceutical industries.
dc.formatapplication/pdfes
dc.format.extent11
dc.identifier.citationPlants, 2023, Vol. 12(3) : 546
dc.identifier.doihttps://doi.org/10.3390/ plants12030546
dc.identifier.issnElectronic: 2223-7747
dc.identifier.urihttp://hdl.handle.net/10201/154719
dc.languageenges
dc.publisherMDPI
dc.relationMinisterio de Ciencia e Innovación (MCIN/AEI/10.13039/501100011033 “Una manera de hacer Europa”) ID2020-113438RB-I00es
dc.relation.publisherversionhttps://www.mdpi.com/2223-7747/12/3/546
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCyclodextrins
dc.subjectIn vitro plants
dc.subjectMethyl jasmonate
dc.subjectMorus alba
dc.subjectOxyresveratrol
dc.subjectResveratrol
dc.titleBiotechnological approach to increase oxyresveratrol production in mulberry in vitro plants under elicitationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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relation.isAuthorOfPublication6a60e21b-276a-41c1-9f7e-16b7c933da77
relation.isAuthorOfPublication4c6e7506-0db4-477e-8704-2a1783040719
relation.isAuthorOfPublication.latestForDiscovery26b10f99-26d5-4ed0-a830-5b27d6665ae6
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