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The role of vascular adhesion molecules PECAM-1 (CD 31), VCAM-1 (CD 106), E-Selectin (CD62E) and P-Selectin (CD62P) in severe porcine pancreatitis

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dc.contributor.authorKleinhans, Helge
dc.contributor.authorKaifi, Jussuf T.
dc.contributor.authorMann, Oliver
dc.contributor.authorReinknecht, Felix
dc.contributor.authorFreitag, Marc
dc.contributor.authorHansen, Bente
dc.contributor.authorSchurr, Paulus G.
dc.contributor.authorIzbicki, Jacob R.
dc.contributor.authorStrate, Tim G.
dc.date.accessioned2013-10-04T14:49:46Z
dc.date.available2013-10-04T14:49:46Z
dc.date.issued2009
dc.description.abstractInflammatory cytokines have been shown to mediate organ damage by their action on vascular endothelia and leukocytes, in part by upregulating the expression of adhesion molecules, which in turn convey transmigration of leukocytes into tissue. The upregulation and activation of vascular cell adhesion molecules on the endothelial cells avail firm leukocyte adhesion to the vascular endothelium and enhance their transmigration and consecutive tissue injury. The aim of this study was to evaluate the expresion of vascular adhesion molecules CD 31 (PECAM-1), CD 106 (VCAM-1), CD 62E (E-Selectin) and CD 62P (P-Selectin) in the pancreas and distant organs of pigs suffering from acute necrotizing pancreatitis (AP). AP was induced in 13 pigs by a combination of intravenous cerulein and intraductal glycodeoxycholic acid. For immunostaining of vascular adhesion molecules slides of porcine pancreas, lung, kidney and liver tissue were stained with monoclonal antibodies (Ab) against PECAM-1-1, VCAM-1 E- and PSELECTIN. The endothelial cell expression of CD 31 (PECAM- 1), CD 106 (VCAM), CD 62E (E-Selectin) and CD 62P (P-SELECTIN) in severe porcine pancreatitis is detectable and upregulation is partly significantly.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/36186
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and histopathology, Vol. 24, nº 5 (2009)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectPancreatitises
dc.subjectVascular adhesion moleculeses
dc.subject.other61 - Medicinaes
dc.titleThe role of vascular adhesion molecules PECAM-1 (CD 31), VCAM-1 (CD 106), E-Selectin (CD62E) and P-Selectin (CD62P) in severe porcine pancreatitises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.24, nº5 (2009)