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Review - Role of Old Antibiotics in the Era of Antibiotic Resistance. Highlighted Nitrofurantoin for the Treatment of Lower Urinary Tract Infection

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dc.contributor.authorMuñoz-Dávila, María José
dc.contributor.departmentGenética y Microbiología
dc.date.accessioned2025-09-18T11:04:05Z
dc.date.available2025-09-18T11:04:05Z
dc.date.issued2014-02-10
dc.description© 2014, The author.___ This document is the published version of a published work that appeared in final form in Antibiotics___ This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0 ____ To access the final edited and published work see: https://doi.org/10.3390/antibiotics3010039
dc.description.abstractAbstract: Bacterial infections caused by antibiotic-resistant isolates have become a major health problem in recent years, since they are very difficult to treat, leading to an increase in morbidity and mortality. Nitrofurantoin is a broad-spectrum bactericidal antibiotic that, through a complex mode of action which is not completely understood, affects both Gram-negative and Gram-positive bacteria. Nitrofurantoin has been used successfully for a long time for the prophylaxis and treatment of acute lower urinary tract infections in adults, children and pregnant women, but the increased emergence of antibiotic resistance has made nitrofurantoin a suitable candidate for the treatment of infections caused by multidrug-resistant pathogens. Here, we review the mechanism of action, antimicrobial spectrum, pharmacology and safety profile of nitrofurantoin. We also investigate the therapeutic use of nitrofurantoin, including recent data which highlight its role in the management of community urinary tract infection, especially in cases of multidrug-resistant isolates, in which oral active antimicrobials are limited resources nowadays.
dc.formatapplication/pdf
dc.format.extent10
dc.identifier.citationAntibiotics 2014, 3, 39-48
dc.identifier.doihttps://doi.org/10.3390/antibiotics3010039
dc.identifier.eissn2079-6382
dc.identifier.urihttps://hdl.handle.net/10201/158749
dc.languageeng
dc.publisherMDPI
dc.relationSin financiación externa a la Universidad
dc.relation.publisherversionhttps://www.mdpi.com/2079-6382/3/1/39
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectUrinary tract infection
dc.subjectTherapeutic use
dc.subjectNitrofurantoin
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleReview - Role of Old Antibiotics in the Era of Antibiotic Resistance. Highlighted Nitrofurantoin for the Treatment of Lower Urinary Tract Infection
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublicationes
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