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The seminal plasma of the boar is rich in cytokines, with significant individual and intra-ejaculate variation

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dc.contributor.authorBarranco Cascales, Isabel
dc.contributor.authorRubér, Marie
dc.contributor.authorPérez Patiño, Cristina
dc.contributor.authorAtikuzzaman, Mohammad
dc.contributor.authorMartínez García, Emilio
dc.contributor.authorRoca Aleu, Jorge
dc.contributor.authorRodríguez Martínez, Heriberto
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2025-10-16T12:46:09Z
dc.date.available2025-10-16T12:46:09Z
dc.date.copyright© 2015 John Wiley & Sons A/S.
dc.date.issued2015-12
dc.description.abstractProblem: The boar, as human, sequentially ejaculates sperm-rich and sperm-poor fractions. Seminal plasma (SP) spermadhesins (PSP-I/PSP-II) induce a primary endometrial inflammatory response in female sows, similar to that elicited by semen deposition in other species, including human. However, the SP is also known to mitigate such response, making it transient to allow for embryo entry to a cleansed endometrium. Although cytokine involvement has been claimed, the exploration of cytokines in different SP fractions is scarce. This study determines Th1, Th2, Th17 and Th3 cytokine profiles in specific ejaculate SP fractions from boars of proven fertility. Methods: SP samples from the sperm-rich fraction (SRF) and the sperm-poor post-SRF fraction (post-SRF) of manually collected ejaculates from eight boars (four ejaculates per boar) were analysed by commercial multiplex bead assay kits (Milliplex MAP, Millipore, USA) for interferon-γ, interferon gamma-induced protein 10, macrophage-derived chemokine, growth-regulated oncogene, granulocyte-macrophage colony-stimulating factor, monocyte chemo-attractant protein-1, interleukins (IL)-6, IL-8, IL-10, IL-15, IL-17 and transforming growth factor (TGF)-β1-β3. Results: Cytokine concentrations differed between the ejaculate fractions among boars, being highest in the post-SRF. Conclusion: Boar SP is rich in Th1, Th2, Th17 and Th3 cytokines, with lowest concentrations in the sperm-peak-containing fraction, indicating its main immune influence might reside in the larger, protein-rich sperm-poor post-SRF.
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dc.format.extent10
dc.identifier.citationAmerican Journal of Reproductive Immunology, 2015, Vol. 74, Issue 6, pp. 523-532
dc.identifier.doi https://doi.org/10.1111/aji.12432
dc.identifier.eissn1600-0897
dc.identifier.issn1046-7408
dc.identifier.urihttp://hdl.handle.net/10201/166752
dc.languageeng
dc.publisherWiley
dc.relationThis experimental study was supported by MINECO(AGL2012-39903) Madrid (Spain), FEDER funds(EU) and Formas (Stockholm, Sweden). I. Barrancoand C. Perez-Pati~no were financially supported byMECD (Madrid, Spain) and Seneca Foundation(Murcia, Spain), respectively. The authors are grate-ful to AIM Iberica for supplying the boar ejaculates.
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/epdf/10.1111/aji.12432
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectEjaculate fractions
dc.subjectImmunomodulatory molecules
dc.subjectPig
dc.subjectSeminal plasma peptides
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleThe seminal plasma of the boar is rich in cytokines, with significant individual and intra-ejaculate variation
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublicationes
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relation.isAuthorOfPublication54a701a0-5cff-4dde-8614-de81f8c2ce55
relation.isAuthorOfPublication032b17bf-c6a7-4745-a513-c02b384cc26c
relation.isAuthorOfPublication.latestForDiscovery3c34d0d5-7d7d-4bcc-a119-8906f53baa7b
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