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Fragmentation of the Golgi complex of dopaminergic neurons in human substantia nigra: new cytopathological findings in Parkinson's disease

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dc.contributor.authorTomás, Mónica
dc.contributor.authorMartínez Martínez, Narcisa
dc.contributor.authorCara Esteban, Mireia
dc.contributor.authorMartínez Alonso, Emma
dc.contributor.authorMartínez Menárguez, José Ángel
dc.date.accessioned2022-12-02T09:52:55Z
dc.date.available2022-12-02T09:52:55Z
dc.date.copyright© 2021 The Author(s)
dc.date.issued2021
dc.description.abstractFragmentation of the Golgi ribbon is a common feature of Parkinson's disease and other neurodegenerative diseases. This alteration could be the consequence of the anterograde and retrograde transport imbalance, α-synuclein aggregates, and/or cytoskeleton alterations. Most information on this process has been obtained from cellular and animal experimental models, and as such, there is little information available on human tissue. If the information on human tissue was available, it may help to understand the cytopathological mechanisms of this disease. In the present study, we analyzed the morphological characteristics of the Golgi complex of dopaminergic neurons in human samples of substantia nigra of control and Parkinson's disease patients. We measured the expression levels of putative molecules involved in Golgi fragmentation, including α-synuclein, tubulin, and Golgi-associated regulatory and structural proteins. We show that, as a consequence of the disease, the Golgi complex is fragmented into small stacks without vesiculation. We found that only a limited number of regulatory proteins are altered. Rab1, a small GTPase regulating endoplasmic reticulum-to-Golgi transport, is the most dramatically affected, being highly overexpressed in the surviving neurons. We found that the SNARE protein syntaxin 5 forms extracellular aggregates resembling the amyloid plaques characteristic of Alzheimer's disease. These findings may help to understand the cytopathology of Parkinson's disease.
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dc.identifier.citationHistol Histopathol (2021) 36: 47-60
dc.identifier.doihttps://doi.org/10.14670/HH-18-270
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/126166
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relation This work was supported by grants from Universidad de Valencia (UV-INV-AE11- 41831) and Consellería de Cultura, Educación y Ciencia (GV/2013/093).es
dc.relation.publisherversionhttps://www.hh.um.es/Abstracts/Vol_36/36_1/36_1_47.htm
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectGolgi complexes
dc.subjectParkinson’s diseasees
dc.subjectDopaminergic neuronses
dc.subjectSubstantia nigraes
dc.subjectMembrane traffices
dc.subjectα-synucleines
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleFragmentation of the Golgi complex of dopaminergic neurons in human substantia nigra: new cytopathological findings in Parkinson's diseasees
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersión
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relation.isAuthorOfPublication7a507105-fec6-4fb0-ba09-bb78ac5a47be
relation.isAuthorOfPublication.latestForDiscovery3fd5eb36-2d6e-4f9e-8e3f-fa44f8982697
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Histology and histopathology Vol.36, nº1 (2021)