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Big roles of microRNAs in tumorigenesis and tumor development

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dc.contributor.authorTie, Jun
dc.contributor.authorFan, Daiming
dc.date.accessioned2016-04-29T17:30:04Z
dc.date.available2016-04-29T17:30:04Z
dc.date.issued2011
dc.description.abstractMicroRNAs (miRNAs) are a class of endogenous non-protein-coding small RNAs that are evolutionarily conserved and widely distributed among species. Their major function is to negatively regulate target gene expression. A single miRNA can regulate multiple target genes, indicating that miRNAs may regulate multiple signaling pathways and participate in a variety of physiological and pathological processes. Currently, approximately 50% of identified human miRNA-coding genes are located at tumor-related fragile chromosome regions. Abnormal miRNA expression and/or mutations have been found in almost all types of malignancies. These abnormally expressed miRNAs play roles similar to tumor suppressor genes or oncogenes by regulating the expression and/or function of tumor-related genes. Therefore, miRNAs, miRNA target genes, and the genes regulating miRNAs form a regulatory network with miRNAs in the hub. This network plays a pivotal role in tumorigenesis and tumor development.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/49450
dc.languageenges
dc.publisherF. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología.es
dc.relation.ispartofHistology and histopathology, Vol. 26, nº10 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMicroRNAen_EN
dc.subjectGene expression regulationsen_EN
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleBig roles of microRNAs in tumorigenesis and tumor developmenten_EN
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26,nº10 (2011)