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The effect of the flavonoid diosmin, grape seed extract and red wine on the pulmonary metastatic B16F10 melanoma

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dc.contributor.authorMartínez, C.es
dc.contributor.authorVicente García, Vicentees
dc.contributor.authorYáñez, J.
dc.contributor.authorAlcaraz, M.
dc.contributor.authorCanteras, M.
dc.contributor.authorBenavente-García García, Obdulio
dc.contributor.authorCastillo, J.
dc.contributor.authorCastells Mora, María Teresa
dc.date.accessioned2011-06-30T12:01:24Z
dc.date.available2011-06-30T12:01:24Z
dc.date.issued2005
dc.description.abstractObjective: To study the effect of different phenolic compounds and red wine on pulmonary metastatic melanoma. Methods: Swiss mice were inoculated with 5x105 melanocytes B16F10 and given oral doses of diosmin, grape seed extract (GSE) and red wine. A macroscopic count was made of the metastatic nodules on the lung surface and a microscopic study by image analysis of five sections, calculating the implantation percentage and tumoral growth and invasion indices. Results: Macroscopically, the group treated with diosmin showed the greatest reduction (52%) in the number of metastatic nodules compared with the control group, which was treated with ethanol, while GSE and red wine caused decreases of 26.07 and 28.81%, respectively. Microscopically, there was a decrease in the implantation percentage after the administration of diosmin (79.4%) and red wine (20.19%), and an increase of 2.12% after the administration of GSE, all relative to the ethanol-treated control. As regards the growth index, diosmin produced a reduction of 67.44% and red wine a reduction of 20.62%, while GSE again produced an increase (25.33%). The reductions in the invasion index were 45.23, 31.65 and 17.57% with diosmin, GSE and red wine, respectively. Conclusions: Diosmin originated the greatest reduction in pulmonary metastases, both at the macroscopic and microscopic levels.es
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dc.format.extent9es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22566
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectPulmonary metastasises
dc.subjectDiosmines
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.2 - Patología del aparato respiratorioes
dc.titleThe effect of the flavonoid diosmin, grape seed extract and red wine on the pulmonary metastatic B16F10 melanomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationd6ad2235-d5ca-4574-85eb-964da3c5c44c
relation.isAuthorOfPublication.latestForDiscoveryd6ad2235-d5ca-4574-85eb-964da3c5c44c
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Histology and histopathology Vol.20, nº 4 (2005)