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In vitro study of the differential anti-inflammatory activity of dietary phytochemicals upon human macrophage-like cells as a previous step for dietary intervention

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dc.contributor.authorRuiz Alcaraz, Antonio José
dc.contributor.authorBaquero, Lorena
dc.contributor.authorMartínez Pérez-Munar, Paula
dc.contributor.authorOliva-Bolarín, Alba
dc.contributor.authorSánchez-Martínez, María A.
dc.contributor.authorRamos-Molina, Bruno
dc.contributor.authorNúñez-Sánchez, María A.
dc.contributor.authorMoreno, Diego A.
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.contributor.otherFacultad de Biología
dc.date.accessioned2026-01-14T07:05:24Z
dc.date.available2026-01-14T07:05:24Z
dc.date.copyright© 2024 by the authors
dc.date.issued2024-10-05
dc.description.abstractChronic inflammatory diseases pose a substantial health challenge globally, significantly contributing to morbidity and mortality. Addressing this issue requires the use of effective anti-inflammatory strategies with fewer side effects than those provoked by currently used drugs. In this study, a range of phytochemicals (phenolic di-caffeoylquinic acid (Di-CQA), flavonoid cyanidin-3,5-diglucoside (Cy3,5DiG), aromatic isothiocyanate sinalbin (SNB) and aliphatic isothiocyanate sulforaphane (SFN)) sourced from vegetables and fruits underwent assessment for their potential anti-inflammatory activity. An in vitro model of human macrophage-like cells treated with a low dose of LPS to obtain a low degree of inflammation that emulates a chronic inflammation scenario revealed promising results. Cell viability and production of the key pro-inflammatory cytokines were assessed in the presence of various phytochemicals. The compounds Di-CQA and Cy-3,5-DiG, within low physiologically relevant doses, demonstrated notable anti-inflammatory effects by significantly reducing the production of key pro-inflammatory cytokines TNF-α and IL-6 without affecting cell viability. These findings underscore the potential of plant-derived bioactive compounds as valuable contributors to the prevention or treatment of chronic inflammatory diseases. These results suggest that these compounds, whether used individually or as part of natural mixtures, hold promise for their inclusion in nutritional interventions designed to mitigate inflammation in associated pathologies.
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dc.format.extent11
dc.identifier.citationInt. J. Mol. Sci. 2024, 25, 10728
dc.identifier.doihttps://doi.org/10.3390/ijms251910728
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10201/186450
dc.languageeng
dc.publisherMDPI
dc.relationThis research was funded by Fundación Séneca (grant numbers 20855/PI/18 (D.A.M.) and 22080/JLI/22 (M.A.N.-S)) and by the Biomedical Research Institute of Murcia (IMIB/CI/09, A.J.R-A). M.A.N.-S. is supported by the “Miguel Servet Type I” program (CP23/00051, ISCIII, Spain; co-funded by the Fondo Europeo de Desarrollo Regional-FEDER). M.A.M-S holds a PFIS predoctoral fellowship from the ISCIII (FI21/0003, ISCIII, Spain; co-funded by the Fondo Europeo de Desarrollo Regional-FEDER). B.R-M is supported by the “Miguel Servet Type I” program (CP19/00098, ISCIII, Spain; co-funded by the Fondo Europeo de Desarrollo Regional-FEDER).
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/25/19/10728
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAnti-inflammatory agents
dc.subjectInflammatory diseases
dc.subjectGlucosinolates
dc.subjectIsothiocyanate
dc.subjectAnthocyanins
dc.subjectPhenolic acids
dc.subjectBioactive phytochemicals
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleIn vitro study of the differential anti-inflammatory activity of dietary phytochemicals upon human macrophage-like cells as a previous step for dietary intervention
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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relation.isAuthorOfPublication.latestForDiscoveryc5d54ef3-bd3b-4330-b4a1-252ab278925b
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