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Atypical spindle cell/pleomorphic lipomatous tumor

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Lecoutere-35-769-778-2020.pdf(5.4 MB)
Date
2020
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Authors
Lecoutere, Evelyne ; Creytens, David
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-210
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info:eu-repo/semantics/article
Description
Abstract
Atypical spindle cell/pleomorphic lipomatous tumor (ASPLT) is a recently described morphologically low-grade and clinically indolent adipocytic tumor, which will be incorporated as a new tumor entity in the upcoming 5th edition of the WHO Classification of Soft tissue and Bone tumors. Histologically, ASPLTs are characterized by ill-defined tumor margins and the presence of variable proportions of mild-to-moderately atypical spindle cells, adipocytes, lipoblasts, pleomorphic multinucleated cells and a myxoid or collagenous extracellular matrix. ASPLTs can show a wide variety of microscopic appearances and there is histologic overlap with diverse mimics. The diagnosis of ASPLT can therefore be challenging. Molecular studies have shown a consistent absence of MDM2 or CDK4 amplification. On the other hand, deletions or losses of 13q14, including RB1, have been identified in a significant subset of cases. This review provides an overview of the currently known clinical and pathological features of ASPLTs, detailing its most relevant differential diagnoses.
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Atypical spindle cell/pleomorphic lipomatous tumor , Atypical spindle cell lipomatous tumor , Atypical pleomorphic lipomatous tumor , RB1 , MDM2 , Liposarcoma , Spindle cell/pleomorphic lipoma
Citation
Histology and Histopathology Vol. 35, nº8 (2020)
URI
http://hdl.handle.net/10201/126085
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Histology and histopathology Vol.35, nº8 (2020)
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