Publication: Metamorphosed fibroblasts and their relation to the histogenesis of malignant fibrous histiocytoma in experimental murine model
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Date
2000
Authors
Osanai, T. ; Yamakawa, Mitsunori ; Suda, A. ; Watanabe, Y.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Malignant fibrous histiocytoma (MFH) is a
clinicopathologically established entity, but its
histogenesis remains to be clarified. We have reported
the existence of a specific cell type, the "fibrohistiocytoid
(FH) cells", in various chronic inflammatory
tissues. The FH cells are the metamorphosed fibroblasts
and we have revealed the morphological resemblance
between FH cells and MFH cells. In the present study
we carried out some experiments to ascertain whether
the FH cells have a possibility of neoplastic potential for
the development of MFH in mice. A total of 50 female
Balb/c mice treated with a chemical carcinogen, 9,lOdimethyl-
1,2-benzanthracene (DMBA), were examined
histopathologically from 8 to 22 weeks after the initial
treatment. It was found that 1) the chemically induced
tumors in the mice resembled human pleomorphic/
storiform variant of MFH and cells from the tumor were
transplantable subcutaneously in the back of another
mouse, 2) the tumors were composed mainly of
malignant FH cells, and there were many benign FH
cells and fibroblasts in granulation tissues obtained at the
initial stage of the experiment, 3) all DNA histograms
obtained from MFHs were aneuploid and granulation
tissues were diploid, and 4) benign FH cells in the
granulation tissue appeared to have higher DNA
synthesis activity than typical fibroblasts on the basis of bromodeoxyuridine (BrdU) labeling and cytofluorometric
studies. From these findings, we suggest that the
FH cells are not only a merely morphologically changed
fibroblast, but also a biologically ominous cell which
may contribute to develop MFH in mice.
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