Publication: Changes in the immunoreactivity of substance P and calcitonin gene-related peptide
in the laryngeal taste buds of chronically hypoxic rats
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Date
2000
Authors
Kusakabe, T. ; Yoshida, T. ; Matsuda, H. ; Yamamoto, Y. ; Hayashida, Y. ; Kawakami, T. ; Takenaka, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The distribution of substance P (SP)- and
calcitonin gene-related peptide (CGRP)-immunoreactive
nerve fibers in the taste buds of the epiglottis and
aryepiglottic folds was compared between normoxic
control and chronically isocapnic hypoxic rats (10% O2
and 3-4% CO2 for 3 months). In the normoxic laryngeal
taste buds, SP- and CGRP-imrnunoreactive fibers were
detected within the taste buds, where they appeared as
thin processes with many varicosities. Most CGRP fibers
showed coexistence with SP, but a few fibers showed the
immunoreactivity of CGRP only. The density of intraand
subgemmal SP and CGRP fibers penetrating into the
laryngeal taste buds was significantly higher in
chronically hypoxic rats than in normoxic control rats.
Water intake in the hypoxic rats was significantly lower
than in the normoxic rats. These results indicate that the
increased density of SP- and CGRP-containing nerve
fibers within the laryngeal taste buds is a predominant
feature of hypoxic adaptation. The altered peptidergic
innervation and reduced water intake support the
hypothesis that the laryngeal taste buds are involved in
water reception, and that the water reception may be
under the control of peptidergic innervation.
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