Publication: A morphological study on the reproductive organs as
a possible cause of developmental abnormalities in
diabetic NOD mice
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Date
1989
Authors
Tatewaki, Reiko ; Otani, Hiroki ; Tanaka, Osamu ; Kitada, Jin-ichi
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The reproductive organs in non-obese
diabetic (NOD) mice were histopathologically studied,
in order to elucidate the relationships between developmental
abnormalities, such as diminkhed rates of implantation
and viable embryos, and structural changes in the
reproductive organs. NOD mice with (NOD-DM) and
without (NOD-N) diabetes mellitus and ICR mice were
compared. The severity of histopathological changes in
the pancreas and in the liver were used as parameters
which indicated the severity of diabetes itself and of the
secondary metabolic disorder. NOD-DM mice exhibited
uterine weight loss, accumulation of lipids in luminal and
glandular epithelium, atrophies of the endometrium and
myometrium and a decrease in the number of muscle cell
layers. They also showed a high concentration of lipid
droplets in ovarian granulosa cells, atretic follicles and
atrophy and lack of lipids in ovarian stroma cells. The
severity of these structural changes in the reproductive
organs corresponded to those of the changes in the
pancreas and the liver. The structural alterations in the
ovary suggested disorder in oocyte maturation. The
structural changes in the uterus appeared to be related to
the decrease in the ratios of implantation and of viable
embryos at post-implantation stage. The present studies
suggest that the impaired structural environment
together with the metabolic environment caused the
abnormal development seen, for example. in the oocyte
maturation, and at the implantation and post-implantation
stage of diabetic mice. It also caused alterations in their
hormonal environment
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