Publication: Lysophosphatidic acid receptors in cancer pathobiology
Authors
Tsujiuchi, Toshifumi ; Araki, Mutsumi ; Hirane, Miku ; Dong, Yan ; Fukushima, Nobuyuki
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Lysophosphatidic acid (LPA) receptors
(LPA1 to LPA6) are G protein-coupled transmembrane
and mediate a variety of biological responses through the
binding of LPA, such as cell proliferation, migration,
morphogenesis and differentiation. Previously, high
secretion levels of LPA were found in blood and ascites
from patients with aggressive ovarian cancer. So far,
numerical studies have demonstrated that LPA signaling
via LPA receptors contributes to the acquisition of
malignant potency by several cancer cells. Moreover,
genetic and epigenetic alterations of LPA receptor genes
have been detected in cancer cells. Therefore, it is
suggested that LPA signaling may be a target molecule
for the establishment of chemoprevention agents in
clinical cancer approaches. Here, we review the current
knowledge for the biological roles of LPA signaling via
LPA receptors in the pathogenesis of cancer cells.
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Citation
Histology and Histopathology, vol. 29, nº 3 (2014)
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