Publication: Pilocytic astrocytoma: a review of genetic and
molecular factors, diagnostic and prognostic markers
Authors
Bikowska-Opalach, Barbara ; Szlufik, Stanisław ; Grajkowska, Wiesława ; Jozwiak, Jaroslaw
item.page.secondaryauthor
item.page.director
Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
In spite of numerous studies concerning the
pathogenesis of pilocytic astrocytoma (PA), the exact
mechanism of the process still remains undetermined. It
is difficult to obtain concordance between particular
studies, which makes review of existing data especially
troublesome. Nevertheless, the most important causative
factors seem to be NF1 gene inactivation, in cases
related to neurofibromatosis type 1, and BRAF gene
overexpression in sporadic PAs, both resulting in
MAPK/Erk pathway upregulation. Other molecular
alterations, like mTOR or PI3K pathway deregulation, or
Matrilin 2 overexpression, may influence the course of
the disease, leading to the development of more
aggressive and recurrent tumors. In the current paper we
review genetic alterations in PA and describe currently
studied molecular markers that may contribute to the
development of the tumor and can be used in
pathological staging of the malformation.
publication.page.subject
Citation
Histology and Histopathology, vol. 29, nº 10, (2014)
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/