Publication: Neutrophil interaction with tumour cells in small early gastric cancer, ultrastructural observations
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Date
1994
Authors
Caruso, R.A. ; Speciale, G. ; Inferrera, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The authors studied the neutrophil
inflammatory reaction by light and electron microscopy
in 4 small early gastric cancers (three tubular adenocarcinomas
and one adenocarcinoma with signet-ring
cell component), selected for the absence of coagulative
necrosis and ulceration. Neutrophils showed ultrastructural
signs of activation such as aggregation,
adhesion and lipid bodies. Some neutrophils were found
to be in intimate contact with the intact tumour cells and
with those that displayed a varying degree of damage.
In particular, relatively early damage, such as
disorganization of the intermediate filaments and
dilatation of the rough endoplasmic reticulum, occurred
at the contact regions. In spite of the severe damage to
the tumour cells, the neutrophils themselves were intact.
These findings are discussed in relationship to a number
of recent studies of the neutrophil-mediated tumour cell
injury, in man and animals.
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Citation
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