Publication:
Gain of function properties of mutant p53 proteins at the mitotic spindle cell cycle checkpoint

Simple item page
dc.contributor.authorHixon, M.L.es
dc.contributor.authorFlores, A.es
dc.contributor.authorWagner, M.
dc.contributor.authorGualberto, A.
dc.date.accessioned2011-02-22T11:21:07Z
dc.date.available2011-02-22T11:21:07Z
dc.date.issued2000
dc.description.abstractMutations in the p53 tumor suppressor gene locus predispose human cells to chromosomal instability. This is due in part to interference of mutant p53 proteins with the activity of the mitotic spindle and postmitotic cell cycle checkpoints. Recent data demonstrates that wild type p53 is required for postmitotic checkpoint activity, but plays no role at the mitotic spindle checkpoint. Likewise, structural dominant p53 mutants demonstrate gain-of-function properties at the mitotic spindle checkpoint and dominant negative properties at the postmitotic checkpoint. At mitosis, mutant p53 proteins interfere with the control of the metaphase-toanaphase progression by up-regulating the expression of CKsl, a protein that mediates activatory phosphorylation of the anaphase promoting complex (APC) by Cdc2. Cells that carry mutant p53 proteins overexpress CKsl and are unable to sustain APC inactivation and mitotic arrest. Thus, mutant p53 gain-of-function at mitosis constitutes a key component to the origin of chromosomal instability in mutant p53 cells.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19294
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCell cyclees
dc.subjectp53es
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleGain of function properties of mutant p53 proteins at the mitotic spindle cell cycle checkpointes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Gain of function properties of mutant p53 proteins at the mitotic spindle cell cycle checkpoint.pdf
Size:
2.86 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.15, nº 2 (2000)